Alice Lupparelli was born in Spello on March 11, 2001. She attended a language-focused high school while also studying dance and violin.

After graduating, she chose to pursue her passion for acting, enrolling at the Centro Sperimentale di Cinematografia in Rome, where she trained for two years while gaining her first on-set experience.

She was among the lead cast of the TV series Un Professore 2, which aired on Rai 1, and, starting November 20, 2024, stars in the new young adult series Adorazione on Netflix.

In 2025, she returned to set for the third season of Un Professore and will also appear on Netflix in the series Maschi Veri, produced by Matteo Rovere. Additionally, she was recently featured in theaters in the film Fuori La Verità, directed by Davide Minnella, alongside an outstanding cast including Claudio Amendola, Claudia Gerini, Claudia Pandolfi, and Leo Gassmann.

In 2026, she will be seen in theaters in Notte prima degli esami 3.0, a remake of the iconic 2000s film.